Lab Overview

Our laboratory studies the development and repair of the mammalian skeleton, with an emphasis on the ribs and handplate. To conduct our experiments, we use standard and conditional knock-out techniques in mouse models and mouse embryonic stem (ES) cells.

  • Embryo lysosomes (Image courtesy of the Mariani Lab)
    Embryo lysosomes (Image courtesy of the Mariani Lab)
  • Lysosomes (Image courtesy of the Mariani Lab)
    Lysosomes (Image courtesy of the Mariani Lab)
  • Fracture callus (Image courtesy of the Mariani Lab)
    Fracture callus (Image courtesy of the Mariani Lab)
  • Fracture callus (Image courtesy of the Mariani Lab)
    Fracture callus (Image courtesy of the Mariani Lab)

  • Double transgenic ribcage (Image courtesy of the Mariani Lab)
    Double transgenic ribcage (Image courtesy of the Mariani Lab)

  • Mouse rib cage stained to show cartilage (blue) and bone (red) (Image by Francesca Mariani)
    Mouse rib cage stained to show cartilage (blue) and bone (red) (Image by Francesca Mariani)
  • Embryonic stem (ES) cells differentiated into neurons (green: nestin-positive stem cells, red: neural-specific b-tubulin) (Image by In Kyoung Mah)
    Embryonic stem (ES) cells differentiated into neurons (green: nestin-positive stem cells, red: neural-specific b-tubulin) (Image by In Kyoung Mah)